Glycosylation Failure Extends to Glycoproteins in Gestational Diabetes Mellitus Evidence From Reduced a2-6 Sialylation and Impaired Immunomodulatory Activities of Pregnancy-Related Glycodelin-A
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Glycosylation Failure Extends to Glycoproteins in Gestational Diabetes Mellitus
OBJECTIVE Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy. Patients with GDM are at risk for high fetal mortality and gestational complications associated with reduced immune tolerance and abnormal carbohydrate metabolism. Glycodelin-A (GdA) is an abundant decidual glycoprotein with glycosylation-dependent immunomodulatory activities. We hypothesized that aberran...
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